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Currently, no single test can precisely assess biological age, as it is influenced by the choice of aging biomarkers, the standards applied, and the statistical method used, including approaches like multiple linear regression (MLR), principal component analysis (PCA), Klemera and Doubals method (KDM), and recent deep learning methods (Li X

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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

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10.3390/antibiotics11030331 371 PrasadA.BharathiV.SivalingamV.GirdharA.PatelB